Ibutamoren, also known as MK-677

 Ibutamoren, also known as MK-677, is a selective agonist of the growth hormone secretagogue receptor (GHSR) that is primarily used for its ability to increase growth hormone and insulin-like growth factor-1 (IGF-1) levels in the body. It has become a popular compound among bodybuilders, athletes, and individuals seeking to improve their physical performance and body composition. Read More about What is Mk677

In this article, we will take a closer look at ibutamoren including its history, mechanism of action, benefits, side effects, and legal status.

History of Ibutamoren

Ibutamoren was initially developed by a pharmaceutical company called Merck, with the aim of creating a drug to combat age-related muscle wasting and osteoporosis. However, the drug was never brought to market, and it remained largely unknown until the early 2000s when it was discovered to have growth hormone-releasing properties.

Mechanism of Action

Ibutamoren works by stimulating the release of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in the body. GH is an important hormone that plays a key role in growth, development, and metabolism. It is produced by the pituitary gland, and its secretion is regulated by several factors, including sleep, exercise, stress, and nutrition.

GH promotes the growth and repair of muscle and bone tissue, increases the body's use of fat for energy, and stimulates the production of IGF-1, which promotes cell growth and division. IGF-1 is also important for maintaining bone density, building muscle, and regulating glucose metabolism.

Ibutamoren acts as a selective agonist of the growth hormone secretagogue receptor (GHSR), which is primarily found in the pituitary gland and hypothalamus. When ibutamoren binds to the GHSR, it stimulates the release of GH and IGF-1, leading to an increase in muscle mass, bone density, and metabolic rate.

Benefits of Ibutamoren

1. Increased Muscle Mass and Strength

Ibutamoren has been shown to increase muscle mass and strength in both healthy individuals and those with muscle-wasting conditions. In a study of healthy older adults, ibutamoren increased lean body mass by an average of 1.6 kg after eight weeks of treatment. Similarly, in a study of patients with chronic heart failure, ibutamoren increased lean body mass by 1.2 kg after 12 weeks of treatment.

2. Improved Bone Density

Ibutamoren has been shown to increase bone density in both healthy individuals and those with osteoporosis. In a study of postmenopausal women with osteoporosis, ibutamoren increased bone mineral density by 1.2% after one year of treatment. Similarly, in a study of healthy older adults, ibutamoren increased bone turnover and bone formation markers, indicating improved bone health.

3. Enhanced Recovery

Ibutamoren has been shown to enhance recovery after exercise and injury. In a study of healthy young men, ibutamoren improved the recovery of muscle strength after a leg press exercise. Similarly, in a study of patients with hip fracture, ibutamoren improved muscle strength and mobility after surgery.

4. Improved Sleep Quality

Ibutamoren has been shown to improve sleep quality in both healthy individuals and those with sleep disorders. In a study of healthy older adults, ibutamoren increased the amount of slow-wave sleep, which is important for rest and recovery. Similarly, in a study of patients with obstructive sleep apnea, ibutamoren improved sleep quality and reduced daytime sleepiness.